Where? : From Las Vegas there are 280 miles all the way to the Grand Canyon south Rim section. Crossing the Hoover Dam, passing through Kingman all the way east near Flagstaff.
What? : You can drive the 280 miles in around 5 hr but I recommend to explore the interesting things on the way, one day road trip with few stops on the way.
When? : Year round.
My thoughts: I highly recommend doing this as a full day drive and see some attractions on the way.
Below list contain many things that can be done along the way. For some of them you need to take from Kingman the longer 66 rout.
Few of them are short stop, other can be few hr visit and for few this is longer overnight visit.
Pictures taken 20 years apart: